Rolling Stone had an article awhile back discussing The Politics of Fear which included this line about former Senator Jesse Helms’ use of gay-baiting during campaigns:
”One of Helms’ political architects told me at the time that it was not about ‘values’ — it was about provoking a visceral, gut-level response,” says Bob Hall, who studied the campaign for the Institute for Southern Studies in Durham, North Carolina. ”It’s not rational — it’s Snakes on a Plane.” Helms, he adds, ”proved the value of gay-baiting in a campaign — even against a moderate opponent. He helped embed it into the culture of the right-wing political operatives.”
This is probably the first time Snakes on a Plane has been used to mean gay-baiting.

OK–I read the article, and I read the paragraph over and over, and the best I can come up with is he is using “Snakes on a Plane” as a metaphor for something that “provokes a visceral, gut-level response”, as opposed to being rational. Like “Pacific Air 121″ is more intellectual, more vague, makes you think, Hmmm, what’s this about? Whereas when you hear “Snakes on a Plane”, it’s not about thinking, it’s about REACTING to–SNAKES ON A PLANE!!! OMG!!! PANIC!!! That kind of thing.
At least, that’s IMHO. ;-)